The Entourage Effect: How Cannabis Compounds Work Together for Better Wellness

by | Apr 9, 2025

Ever wonder why one cannabis strain leaves you mellow and ready for bed, while another sparks energy and creativity – even if they have the same THC content? This isn’t your imagination; it’s the cannabis plant’s entourage effect at work. We often meet folks in our Muskoka cannabis store who are curious about this concept. Let’s break down what the entourage effect is, why it matters for your wellness, and how things like terpenes and minor cannabinoids play a role. Understanding this synergy can help you, with welcome assistance from our staff of course, pick the perfect product at The Green Bouquet Cannabis.

What Is the Entourage Effect?

The entourage effect is the idea that cannabis works best as a team. The plant contains dozens of compounds – including THC, CBD, terpenes, flavonoids and minor cannabinoids – and they work together to shape your experience. In short, the whole plant is often more effective than isolated compounds. CBD can mellow out THC’s effects, while certain terpenes can uplift or relax the high. This synergy is what we call the entourage effect.

The entourage effect highlights the benefits of whole-plant cannabis versus isolates. Whole-plant (or “full-spectrum”) products retain a broader range of cannabinoids and terpenes. Many users report better symptom relief from full-spectrum products, whether for sleep, anxiety, or pain. If you’ve ever found that pure THC or CBD products didn’t quite work, it may be because they were missing those helpful supporting compounds.

Terpenes: Cannabis Aromas with Impact

Terpenes are aromatic oils found in cannabis that influence how each strain smells and feels. Beyond their scents, terpenes interact with cannabinoids to shape your experience. 

Here are a few key players:

  • Myrcene: Earthy and musky. Known for relaxation and sedation. Found in Granddaddy Purple, OG Kush.
  • Limonene: Citrusy and uplifting. Mood-boosting and stress-reducing. Found in Super Lemon Haze.
  • Linalool: Floral and calming. Great for anxiety and stress. Common in Amnesia Haze.
  • Pinene: Pine-scented and clarifying. Helps alertness and memory. Found in Jack Herer, Blue Dream.
  • Caryophyllene: Spicy and peppery. Binds to CB2 receptors for pain and inflammation relief. Found in GSC.

These “entourage effect” terpenes enhance or balance the effects of THC and CBD.

Flavonoids: Cannabis flavour, Aromas and Some Colours

Flavonoids in cannabis and other plants are what provides the delicious flavours we have come to enjoy. They also have been found to give the cannabis plant some of its lovely colours that we have all come to admire during the growing season. They are what provides the deep yellow, blues, purples and pinks that you can find on the sugar leaves. There are various types of flavonoids but we are just focusing on the over experiences. 

Key things to keep in mind:

  • Flavonoids in plants are what is secreted out to the environment to attract pollinators to the plant.
  • There is currently a ton of research being done on flavonoids, so we know a lot more is coming through the pipeline for the specific health benefits they offer.
  • There are over 5000 Flavonoids found in various plants. 
  • Russ Hudson, who is a researcher and author is making heads way, his latest book: The Formidable Book of Flavonoids is worth the read if you are interested. 

Minor Cannabinoids in the Entourage Effect

Cannabis also produces lesser-known cannabinoids that play a supporting role in the entourage effect:

  • CBG (Cannabigerol): Non-intoxicating, known for promoting focus and calm.
  • CBC (Cannabichromene): May enhance mood and reduce pain.
  • CBN (Cannabinol): Mildly psychoactive and often used for sleep support.
  • THCV (Tetrahydrocannabivarin): Can promote energy and mental clarity.

These minor cannabinoids may only appear in small amounts, but they can influence how you feel when paired with the right terpenes and THC/CBD ratios.

A Mood Menu: Tailoring Cannabis and the Entourage Effect to Your Needs

Understanding terpenes and cannabinoids can help you select products that match your goals. Here’s a quick guide:

  • Sleep: Look for myrcene, linalool, and CBN. Try Granddaddy Purple or an indica oil.
  • Focus: Choose pinene and CBG. Jack Herer or Green Crack are solid options.
  • Pain Relief: Seek out caryophyllene, myrcene, and CBD. Cannatonic or 1:1 products work well.
  • Anxiety: Opt for high CBD with linalool or limonene. Harle-Tsu and ACDC are good picks.
  • Creativity: Look for limonene and THCV. Try Super Lemon Haze or Durban Poison.

This “mood menu” is a great starting point to explore the entourage effect with intention.

What Cannabis Research Suggests About The Entourage Effect

Scientific research is still catching up, but early findings are promising. One study found that THC combined with limonene reduced anxiety compared to THC alone. Others show that full-spectrum extracts may be more effective than isolates for pain, sleep, and mood disorders. While more studies are needed, anecdotal reports and preliminary data suggest the entourage effect is real and worth exploring.

How to Shop for Entourage Effect Benefits

At The Green Bouquet Cannabis, we encourage our customers to take an informed and personalized approach to their cannabis experience. Ask about terpene profiles when purchasing flower or vape products, as these compounds play a key role in the effects you may feel. When choosing oils or edibles, look for full-spectrum or whole-plant extracts to benefit from a wider range of cannabinoids and terpenes. Be sure to share your wellness goals—such as better sleep, increased energy, or improved focus—so we can help recommend products that align with your needs. Finally, explore different products and track your experiences to discover what works best for your body.

Terpenes and minor cannabinoids may not be as flashy as THC percentages, but they are essential to how cannabis makes you feel. Think of them as the steering wheel and suspension on a car. They don’t power the ride, but they sure shape it.

Let Nature Work in Harmony

The entourage effect reminds us that cannabis isn’t about one compound doing all the work. It’s about harmony between cannabinoids, flavonoids, terpenes, and your own body. Next time you visit our cannabis Muskoka store, chat with a budtender about your needs. We’ll help you navigate terpenes, strain profiles, and product types so you can enjoy the full bouquet of what cannabis has to offer.

Your ideal experience might not come from the highest THC product on the shelf. It might come from the one with the right ensemble of compounds – your perfect entourage.

Stop by The Green Bouquet Cannabis and let us help you find your match. We’re always happy to talk!